Significant association of dupA of Helicobacter pylori with duodenal ulcer development 5 in South East Indian Population
نویسندگان
چکیده
1 No. JMM/2011/038398 2 3 4 Significant association of dupA of Helicobacter pylori with duodenal ulcer development 5 in South East Indian Population 6 7 8 Jawed Alam 1 , Sankar Maiti 2 , Prachetash Ghosh 1 , Ronita De 1 , Abhijit Chowdhury 3 , 9 Suryasnata Das 4 , Ragini Macaden 4 , Harshad Devarbhavi 4 , T. Ramamurthy 1 , and Asish 10 K. Mukhopadhyay 1 * 11 12 13 14 15 1) National Institute of Cholera and Enteric Diseases, Kolkata-700010, India; 2) IISER, 16 Kolkata; 3) Centre for Liver Research, School of Digestive and Liver Diseases, 17 Institute of Post Graduate Medical Education & Research, Kolkata; 4) St. John's 18 Medical College Hospital, Bangalore 19 20
منابع مشابه
Association of Intact dupA (dupA1) rather than dupA1 cluster with duodenal ulcer in Indian population
BACKGROUND The duodenal ulcer promoting gene (dupA) and dupA cluster in Helicobacter pylori have been described as a risk factor for duodenal ulcer development in some populations. Polymorphic gene dupA can be divided into two groups, intact dupA1 (long or short type based on the presence or absence of 615-bp extra sequences at the 5' region) having complete reading frame and other truncated du...
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Helicobacter pylori (H. pylori) is the pivotal cause of chronic gastritis, peptic ulcer diseases (PUD) and gastric cancer. Morphologically, the bacterium is spiral, Gram-negative and microaerophilic which survives lifespan in the human stomach in case of weak antibiotic therapy. There is a major difference in the pattern of global prevalence of H. pylori infection based on different levels of u...
متن کاملThe intact dupA cluster is a more reliable Helicobacter pylori virulence marker than dupA alone.
The duodenal ulcer promoting (dupA) gene, located in the plasticity region of Helicobacter pylori, is associated with duodenal ulcer development. dupA was predicted to form a type IV secretory system (T4SS) with vir genes around dupA (dupA cluster). We investigated the prevalence of dupA and dupA clusters and clarified associations between the dupA cluster status and clinical outcomes in the U....
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BACKGROUND The prevalence of H. pylori is as high as 60-70% in Chinese population. Although duodenal ulcer and gastric cancer are both caused by H. pylori, they are at opposite ends of the spectrum and as such are considered mutually exclusive. Duodenal ulcer promoting (dupA) gene was reported to be associated with duodenal ulcer development. The aim of this study was to determine the prevalenc...
متن کاملSystematic review and meta-analysis: the relationship between the Helicobacter pylori dupA gene and clinical outcomes
BACKGROUND In 2005, the first disease-specific Helicobacter pylori virulence factor that induced duodenal ulcer and had a suppressive action on gastric cancer has been identified, and was named duodenal ulcer promoting gene (dupA). However, the importance of the dupA gene on clinical outcomes is conflicting in subsequent studies. The aim of this study was to estimate the magnitude of the risk f...
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